Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels.

Abstract excerpt

Mutations in cardiac Na(+) and K(+) channels can disrupt the precise balance of ionic currents that underlies normal cardiac excitation and relaxation. Disruption of this equilibrium can result in arrhythmogenic phenotypes leading to syncope, seizures, and sudden cardiac death. Congenital defects...

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