Article
Molecular basis of arrhythmias.
Circulation - 18 Oct 2005
Shah Manish, Akar Fadi G, Tomaselli Gordon F
Abstract excerpt
The characterization of single gene disorders has provided important insights into the molecular pathogenesis of cardiac arrhythmias. Primary electrical diseases including long-QT syndrome, short-QT syndrome, Brugada syndrome, and catecholaminergic polymorphic ventricular tachycardia have been associated with mutations in a variety of ion channel subunit genes that promote arrhythmogenesis. Pathological...
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