Article
Streptococcus pyogenes pharyngeal isolates with reduced susceptibility to ciprofloxacin in Spain: mechanisms of resistance and clonal diversity.
Antimicrobial agents and chemotherapy - 1 Jan 2005
Albertí Sebastián, Cortés Guadalupe, García-Rey Cesar, Rubio Carmen, Baquero Fernando, García-Rodríguez José Angel, Bouza Emilio, Aguilar Lorenzo
Abstract excerpt
A survey of emm gene sequences and an analysis of the pulsed-field electrophoretic profiles of 30 Streptococcus pyogenes isolates with reduced susceptibilities to ciprofloxacin detected the prevalence of isolates with emm type 6 and considerable genetic diversity among isolates. The mechanism of ciprofloxacin resistance in these isolates was based on point mutations in topoisomerase IV subunit C encoded by parC,...
Topics
- Adolescent
- Adult
- Anti-Infective Agents
- Antigens, Bacterial
- Bacterial Outer Membrane Proteins
- Carrier Proteins
- Child
- Child, Preschool
- Ciprofloxacin
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Genetic Variation