Article
Conditional osmotic stress in yeast: a system to study transport through aquaglyceroporins and osmostress signaling.
The Journal of biological chemistry - 25 Feb 2005
Karlgren Sara, Pettersson Nina, Nordlander Bodil, Mathai John C, Brodsky Jeffrey L, Zeidel Mark L, Bill Roslyn M, Hohmann Stefan
Abstract excerpt
The accumulation and transport of solutes are hallmarks of osmoadaptation. In this study we have employed the inability of the Saccharomyces cerevisiae gpd1Delta gpd2Delta mutant both to produce glycerol and to adapt to high osmolarity to study solute transport through aquaglyceroporins and the control of osmostress-induced signaling. High levels of different polyols, including glycerol, inhibited growth of the...
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