Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

hTERT antagonizes p53-induced apoptosis independently of telomerase activity.

Oncogene - 17 Feb 2005

Rahman Rubaiyat, Latonen Leena, Wiman Klas G

Abstract excerpt

The p53 tumor suppressor controls cell growth and survival through transcriptional regulation of gene expression. Previously, we found that the human telomerase reverse transcriptase (hTERT) gene is downregulated by p53. To investigate if hTERT downregulation has a role in p53-dependent apoptosis, we tested if constitutive expression of telomerase could inhibit p53-induced apoptosis. Here we show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Colonic Neoplasms
Share to Down-Regulation
Share to Burkitt Lymphoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma

Share to Fluorouracil

Share to Mitomycin

Share to Telomerase

Share to Tumor Suppressor Proteins

Source

Identifiers

PMID: 15608686
DOI: 10.1038/sj.onc.1208232

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

hTERT antagonizes p53-induced apoptosis independently of telomerase activity.PMID 15608686Read ↗

Downregulation of telomerase reverse transcriptase mRNA expression by wild type p53 in human tumor cells.Semantic proximity Read ↗

p53-dependent down-regulation of telomerase is mediated by p21waf1.Semantic proximity Read ↗

Wild-type p53-triggered apoptosis is inhibited by bcl-2 in a v-myc-induced T-cell lymphoma line.Semantic proximity Read ↗

Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factorSemantic proximity Read ↗

Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence.Semantic proximity Read ↗

Disruption of p53 function in immortalized human cells does not affect survival or apoptosis after taxol or vincristine treatment.Semantic proximity Read ↗

A Novel Telomerase-Specific Gene Therapy: Gene Transfer of Caspase-8 Utilizing the Human Telomerase Catalytic Subunit Gene PromoterSemantic proximity Read ↗

Growth arrest in ovarian cancer cells by hTERT inhibition short-hairpin RNA targeting human telomerase reverse transcriptase induces immediate growth inhibition but not necessarily induces apoptosis in ovarian cancer cells.Semantic proximity Read ↗

Expression of telomerase inhibits hydroxyl radical‐induced apoptosis in normal telomerase negative human lung fibroblastsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.