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Article

Transcriptional profile of a myotube starvation model of atrophy

18 Dec 2004

Abstract excerpt

Skeletal muscle wasting is a pervasive phenomenon that can result from a wide range of pathological conditions as well as from habitual muscular inactivity. The present work describes a cell-culture condition that induces significant atrophy in skeletal muscle C2C12 myotubes. The failure to replenish differentiation media in mature myotubes leads to rapid atrophy (53% in diameter), which is referred to here as...

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PMID: 15608089
DOI: 10.1152/japplphysiol.01055.2004

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