Article
Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.
Journal of biochemistry and molecular biology - 30 Nov 2004
Ahn Jiwon, Chung Kyung-Sook, Kim Dong-Uk, Won Misun, Kim Lila, Kim Kyung-Shin, Nam Miyoung, Choi Shin-Jung, Kim Hyoung-Chin, Yoon Michung, Chae Suhn-Kee, Hoe Kwang-Lae
Abstract excerpt
The hepatitis C virus is associated with the development of liver cirrhosis and hepatocellular carcinomas. Among the 10 polyproteins produced by the virus, no function has been clearly assigned to the non-structural 5A (NS5A) protein. This study was designed to identify the hepatocellular proteins that interact with NS5A of the HCV. Yeast two-hybrid experiments were performed with a human liver cDNA prey-library,...
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