Article
Discordant expression of HLA class II-associated co-chaperones and HLA-DRB alleles in cultured fibroblast-like synoviocytes.
Human immunology - 1 Dec 2004
Spurrell David R, Oldford Sharon A, Frost Toby, Larsen Bodil, Codner Dianne, Edgecombe Allison, Drover Sheila
Abstract excerpt
Human leukocyte antigen (HLA)-DR-positive synovial fibroblasts are frequently observed in rheumatoid arthritis (RA) and may be implicated in the autoimmune reaction because RA is associated with certain HLA-DRB1* alleles. The question of whether components of the class II antigen presentation pathway and specific DRB alleles are efficiently expressed by synovial fibroblasts is germane to this hypothesis. To...
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