Article
Conserved ERAD-like quality control of a plant polytopic membrane protein.
The Plant cell - 1 Jan 2005
Müller Judith, Piffanelli Pietro, Devoto Alessandra, Miklis Marco, Elliott Candace, Ortmann Bodo, Schulze-Lefert Paul, Panstruga Ralph
Abstract excerpt
The endoplasmic reticulum (ER) of eukaryotic cells serves as a checkpoint tightly monitoring protein integrity and channeling malformed proteins into different rescue and degradation routes. The degradation of several ER lumenal and membrane-localized proteins is mediated by ER-associated protein degradation (ERAD) in yeast (Saccharomyces cerevisiae) and mammalian cells. To date, evidence for the existence of...
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