Article
Microsatellite association mapping of a primary osteoarthritis susceptibility locus on chromosome 6p12.3-q13.
Arthritis and rheumatism - 1 Dec 2004
Southam Lorraine, Dowling Barbara, Ferreira Athena, Marcelline Lucy, Mustafa Zehra, Chapman Kay, Bentham Graham, Carr Andrew, Loughlin John
Abstract excerpt
OBJECTIVE: To test a high density of microsatellite markers from within a primary osteoarthritis (OA) locus on chromosome 6 for association with OA as a means of narrowing and focusing our search for the susceptibility gene. METHODS: One hundred forty-six families, each with 2 or more women concordant for primary OA (ascertained by total hip replacement), were genotyped for 36 microsatellite markers from within a...
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