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Article

RNA interference acts as a natural antiviral response to O'nyong-nyong virus ( <i>Alphavirus</i> ; Togaviridae) infection of <i>Anopheles gambiae</i>

6 Dec 2004

Abstract excerpt

RNA interference (RNAi) is triggered in eukaryotic organisms by double-stranded RNA (dsRNA), and it destroys any mRNA that has sequence identity with the dsRNA trigger. The RNAi pathway in Anopheles gambiae can be silenced by transfecting cells with dsRNA derived from exon sequence of the A. gambiae Argonaute2 (AgAgo2) gene. We hypothesized that RNAi may also act as an antagonist to alphavirus replication in A....

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PMID: 15583140
DOI: 10.1073/pnas.0406983101

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