Article
Common allelic variants of exons 10, 12, and 33 of the thyroglobulin gene are not associated with autoimmune thyroid disease in the United Kingdom.
The Journal of clinical endocrinology and metabolism - 1 Dec 2004
Collins J E, Heward J M, Howson J M M, Foxall H, Carr-Smith J, Franklyn J A, Gough S C L
Abstract excerpt
Thyroglobulin (Tg) is a major autoantigen for autoimmune thyroid disease (AITD). The Tg gene (Tg) has been mapped to chromosome 8q24, which has recently been linked in two independent studies to AITD. Association of specific alleles of microsatellite markers within Tg itself supports a role for Tg as a good candidate susceptibility locus for AITD. Resequencing of the Tg exons has led to the identification of a...
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