Article
[Osteoporosis and gene polymorphism].
Clinical calcium - 1 Feb 2004
Hosoi Takayuki
Abstract excerpt
Osteoporosis is a multifactorial disease for which genetic and environmental factors are determinants. We have been conducting a candidate-gene approach in which polymorphisms of many bone metabolism related genes have been examined in the association study with bone mineral density and fracture incidence. However, the contribution of each gene is small and the major genetic determinants of BMD have not...
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