Article
Comparison between siblings and twins supports a role for modifier genes in ADPKD.
Kidney international - 1 Dec 2004
Persu Alexandre, Duyme Michel, Pirson Yves, Lens Xosé M, Messiaen Thierry, Breuning Martijn H, Chauveau Dominique, Levy Micheline, Grünfeld Jean-Pierre, Devuyst Olivier
Abstract excerpt
BACKGROUND: Autosomal-dominant polycystic kidney disease (ADPKD) is characterized by intrafamilial variability in renal disease progression, which could result from a combination of environmental and genetic factors. Although a role for modifier genes has been evidenced in mouse models, direct evidence in ADPKD patients is lacking. The analysis of variability in affected siblings and monozygotic (MZ) twins would...
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