Article
Cytokine gene polymorphisms in endemic pemphigus foliaceus: a possible role for IL6 variants.
Cytokine - 21 Dec 2004
Pereira Noemi Farah, Hansen John A, Lin Ming-Tseh, Roxo Valéria Maria Munhoz Sperandio, Braun Karin, Petzl-Erler Maria Luiza
Abstract excerpt
Endemic pemphigus foliaceus (EPF) is a complex autoimmune disease characterized by the presence of antibodies against desmoglein 1, which lead to the loss of adhesion among keratinocytes (acantholysis). Variants of HLA class II genes have been the only genetic factors found to modulate susceptibility to EPF. This study aims at investigating the influence of cytokine genetic variants in the pathogenesis of EPF,...
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