Article
RpoB gene mutations in rifampin-resistant Mycobacterium tuberculosis strains isolated in the Aegean region of Turkey.
Journal of chemotherapy (Florence, Italy) - 1 Oct 2004
Avkan Oguz V, Eroglu C, Guneri S, Yapar N, Oztop A, Sanic A, Yuce A
Abstract excerpt
Although DNA sequencing method has not been used routinely for detecting resistance of Mycobacterium tuberculosis to antituberculosis drugs, it is suggested for the investigation of gene mutations causing resistance. Using DNA sequencing (Automated Applied Biosystems), we attempted to determine mutations in the 81-bp cor region (rifampin resistance determining region) of the rpoB gene in 48 Mycobacterium...
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