Article
Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain.
European archives of psychiatry and clinical neuroscience - 1 Aug 2005
Hampel Harald, Haslinger Andreas, Scheloske Michael, Padberg Frank, Fischer Petra, Unger Josef, Teipel Stefan Johannes, Neumann Michaela, Rosenberg Carlyn, Oshida Rusti, Hulette Christine, Pongratz Dieter, Ewers Michael, Kretzschmar H A, Möller Hans-Jürgen
Abstract excerpt
Involvement of the interleukin-6 receptor complex (IL-6RC) in neuroregulatory and immunological processes of the brain and particularly in Alzheimer's disease (AD) has been hypothesized. The functionally active IL-6RC consists of the cytokine IL-6, which acts through the ligand binding IL-6R and the signal transducing gp130. Using a new immunocytochemical protocol on rapid autopsy cryostat brain sections we...
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