Article
Role of Nedd4 and ubiquitination of Rous sarcoma virus Gag in budding of virus-like particles from cells.
Journal of virology - 1 Dec 2004
Vana Marcy L, Tang Yi, Chen Aiping, Medina Gisselle, Carter Carol, Leis Jonathan
Abstract excerpt
Rous sarcoma virus (RSV) budding requires an interaction of the L domain within the p2b region of Gag with cellular Nedd4-family E3 ubiquitin protein ligases. Members of our laboratories previously demonstrated that overexpression of a fragment of the chicken Nedd4-like protein (LDI-1 WW) inhibits Gag release in a dominant-negative manner (A. Kikonyogo, F. Bouamr, M. L. Vana, Y. Xiang, A. Aiyar, C. Carter, and J....
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