Article
Genetic analyses of two cases of Werner's syndrome.
European journal of dermatology : EJD - 1 Jan 2000
Sogabe Yoko, Yasuda Masahito, Yokoyama Yoko, Tamura Atsushi, Negishi Izumi, Ohnishi Kazunori, Shinozaki Tetsuya, Ishikawa Osamu
Abstract excerpt
We report two cases of Werner's syndrome (WS). First, a 42-year-old Japanese man was referred on suspicion of systemic sclerosis (SSc) because of scleroderma-like skin atrophy and foot ulcers. Second, a 51-year-old woman with malignant fibrous histiocytoma was referred on suspicion of premature aging syndrome. Because both patients had many typical manifestations compatible with WS, we made a clinical diagnosis...
Topics
- Adult
- DNA Helicases
- DNA Primers
- Diagnosis, Differential
- Exodeoxyribonucleases
- Female
- Foot Ulcer
- Humans
- Male
- Middle Aged
- Mutation
- Polymerase Chain Reaction