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Article

Antibacterial activity of a competence-stimulating peptide in experimental sepsis caused by Streptococcus pneumoniae.

Antimicrobial agents and chemotherapy - 1 Dec 2004

Oggioni Marco R, Iannelli Francesco, Ricci Susanna, Chiavolini Damiana, Parigi Riccardo, Trappetti Claudia, Claverys Jean-Pierre, Pozzi Gianni

Abstract excerpt

Streptococcus pneumoniae, a major cause of human disease, produces a 17-mer autoinducer peptide pheromone (competence-stimulating peptide [CSP]) for the control of competence for genetic transformation. Due to previous work linking CSP to stress phenotypes, we set up an in vivo sepsis model to assay its effect on virulence. Our data demonstrate a significant increase in the rates of survival of mice, reductions...

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Identifiers

PMID: 15561850
DOI: 10.1128/AAC.48.12.4725-4732.2004
PMCID: PMC529211

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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