Article
Stimulation of phagocytosis of influenza virus-infected cells through surface desialylation of macrophages by viral neuraminidase.
Microbiology and immunology - 1 Jan 2004
Watanabe Yuichi, Shiratsuchi Akiko, Shimizu Kazufumi, Takizawa Takenori, Nakanishi Yoshinobu
Abstract excerpt
Cells infected with influenza A virus undergo apoptosis and become susceptible to phosphatidylserine-mediated phagocytosis by macrophages. This study was undertaken to elucidate the mechanism underlying our previous finding that the activity of viral neuraminidase (NA) is required for efficient phagocytosis. Treatment of macrophages, not influenza virus-infected cells, with Arthrobacter ureafaciens NA or...
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