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Article

Invadolysin: a novel, conserved metalloprotease links mitotic structural rearrangements with cell migration.

The Journal of cell biology - 22 Nov 2004

McHugh Brian, Krause Sue A, Yu Bin, Deans Anne-Marie, Heasman Sarah, McLaughlin Paul, Heck Margarete M S

Abstract excerpt

The cell cycle is widely known to be regulated by networks of phosphorylation and ubiquitin-directed proteolysis. Here, we describe IX-14/invadolysin, a novel metalloprotease present only in metazoa, whose activity appears to be essential for mitotic progression. Mitotic neuroblasts of Drosophila melanogaster IX-14 mutant larvae exhibit increased levels of nuclear envelope proteins, monopolar and asymmetric...

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Identifiers

PMID: 15557119
DOI: 10.1083/jcb.200405155
PMCID: PMC2172566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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