Article
Synaptic scaffolding molecule is involved in the synaptic clustering of neuroligin.
Molecular and cellular neurosciences - 1 Dec 2004
Iida Junko, Hirabayashi Susumu, Sato Yuji, Hata Yutaka
Abstract excerpt
S-SCAM has a similar molecular organization to PSD-95. Both of them interact with a cell adhesion molecule, neuroligin. We previously reported that beta-catenin binds S-SCAM and recruits it to synapses. We have here examined using rat primary cultured neurons whether neuroligin recruits S-SCAM to synapses or S-SCAM determines the localization of neuroligin. Overexpressed neuroligin formed larger clusters under...
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