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NKG2D Recognition and Perforin Effector Function Mediate Effective Cytokine Immunotherapy of Cancer

15 Nov 2004

Abstract excerpt

Single and combination cytokines offer promise in some patients with advanced cancer. Many spontaneous and experimental cancers naturally express ligands for the lectin-like type-2 transmembrane stimulatory NKG2D immunoreceptor; however, the role this tumor recognition pathway plays in immunotherapy has not been explored to date. Here, we show that natural expression of NKG2D ligands on tumors provides an...

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PMID: 15545356
DOI: 10.1084/jem.20041522

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