Article
Lymphoid gene expression as a predictor of risk of secondary brain tumors.
Genes, chromosomes & cancer - 1 Feb 2005
Edick Mathew J, Cheng Cheng, Yang Wenjian, Cheok Meyling, Wilkinson Mark R, Pei Deqing, Evans William E, Kun Larry E, Pui Ching-Hon, Relling Mary V
Abstract excerpt
Gene expression profiles are tissue-specific but may also reflect germ-line-driven expression patterns across tissue types. Previously, using a targeted pharmacologic approach, we identified germ-line polymorphisms in a single gene (thiopurine methyltransferase) associated with the risk of irradiation- and chemotherapy-induced secondary brain tumors in children with acute lymphoblastic leukemia (ALL). To identify...
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