Article
Influence of anoxia on the induction of mutations by phenylalanine radicals during gamma-irradiation of plasmid DNA in aqueous solution.
Mutation research - 21 Dec 2004
Kuipers Gitta K, Slotman Ben J, Reitsma-Wijker Carola A, van Andel Rob J, Poldervaart Hester A, Lafleur M Vincent M
Abstract excerpt
When DNA is irradiated in aqueous solution, most of the damage is inflicted by water-derived radicals. This is called the indirect effect of ionizing radiation. However in whole cells not only the primary formed water radicals play a role, because some cellular compounds form secondary radicals which can also damage DNA. It is known that the amino acid phenylalanine is able to react with water radicals, resulting...
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