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Article

Differential gene expression in rat colon by dietary heme and calcium

24 Jun 2004

Abstract excerpt

Dietary heme and calcium are alleged modulators of colon cancer risk. Little is known about the molecular and cellular changes in the colon epithelium that are induced by consumption of these unabsorbed nutrients. In this nutrigenomics study, we fed rats high- and low-calcium diets with or without heme. In agreement with previous studies, we found that dietary heme increased the cytotoxicity of fecal water in the...

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PMID: 15539406
DOI: 10.1093/carcin/bgh288

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