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Article

Structural stability of wild type and mutated alpha-keratin fragments: molecular dynamics and free energy calculations.

Biomacromolecules - 1 Jan 2000

Danciulescu Cristian, Nick Birgitta, Wortmann Franz-Josef

Abstract excerpt

The objective of this study is to investigate the influence of point mutations on the structural stability of coiled coil fragments of the human hair intermediate filament by molecular dynamics simulations and free energy calculations. Mutations in the helix termination motif of human hair keratin gene hHb6 seem to be connected to the hereditary hair dystrophy Monilethrix. The most common mutations reported are...

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PMID: 15530030
DOI: 10.1021/bm049788u

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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