Article
Autoreactive CD8+ cytotoxic T lymphocytes to major histocompatibility complex class I chain–related gene A in patients with Behçet's disease
1 Nov 2004
Abstract excerpt
OBJECTIVE: To detect and characterize the autoreactive CD8+ T cells to major histocompatibility complex class I chain-related gene A (MICA), a stress-inducible antigen preferentially expressed on the epithelium and endothelium, in patients with Behcet's disease (BD). METHODS: A candidate for the antigenic MICA peptide was selected based on its predicted binding affinity for HLA-B51 and proteasomal cleavage sites....
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