Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus.

Journal of neurochemistry - 1 Nov 2004

McMillan Pamela J, Wilkinson Charles W, Greenup Lynne, Raskind Murray A, Peskind Elaine R, Leverenz James B

Abstract excerpt

Glucocorticoids regulate plasticity and survival of hippocampal neurons. Aberrant exposure to this steroid hormone can result in neurodegeneration, perhaps secondary to disruption of calcium homeostasis. Calbindin, a calcium-binding protein that buffers excess calcium, may protect against neurodegeneration resulting from overabundance of intracellular calcium. In this study, we examined whether chronic treatment...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calbindin 2
Share to Calbindins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dentate Gyrus

Share to Glutamate Decarboxylase

Share to Macaca nemestrina

Share to Parvalbumins

Share to S100 Calcium Binding Protein G

Source

Identifiers

PMID: 15525338
DOI: 10.1111/j.1471-4159.2004.02760.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chronic cortisol exposure promotes the development of a GABAergic phenotype in the primate hippocampus.PMID 15525338Read ↗

Circadian regulation of hippocampal function is disrupted with chronic corticosteroid treatmentSemantic proximity Read ↗

Increased Cortisol and Antiglucocorticoid Therapy in Mood Disorders: The Hippocampus as a Potential Drug TargetSemantic proximity Read ↗

Childhood adversity and allostatic overload of the hypothalamic-pituitary-adrenal axis: a vulnerability model for depressive disorders.Semantic proximity Read ↗

Previous History of Chronic Stress Changes the Transcriptional Response to Glucocorticoid Challenge in the Dentate Gyrus Region of the Male Rat HippocampusSemantic proximity Read ↗

Glucocorticoid effects on the brain: from adaptive developmental plasticity to allostatic overloadSemantic proximity Read ↗

Differential regulation of gene expression pathways with dexamethasone and ACTH after early life seizuresSemantic proximity Read ↗

Glucocorticoid-Dependent Hippocampal Transcriptome in Male Rats: Pathway-Specific Alterations With AgingSemantic proximity Read ↗

Transcriptome signatures of the medial prefrontal cortex underlying GABAergic control of resilience to chronic stress exposureSemantic proximity Read ↗

Genomic glucocorticoid receptor effects guide acute stress-induced delayed anxiety and basolateral amygdala spine plasticity in ratsSemantic proximity Read ↗

Acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of BDNFVal/Met mice.Semantic proximity Read ↗

Chronic stress-mutated presenilin 1 gene interaction perturbs neurogenesis and accelerates neurodegeneration.Semantic proximity Read ↗

Chemogenetic Inhibition of Infralimbic Prefrontal Cortex GABA-ergic Parvalbumin Interneurons Attenuates Chronic Stress Adaptions in Male MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.