Article
A new immune-competent animal model of mucosally derived squamous cell carcinoma.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery - 1 Nov 2004
Djalilian Hamid R, Lessan Khashayar, Grami Vahid, Pambuccian Stefan E, Spellman Stephen R, Low Walter C, Hall Walter A, Ondrey Frank G
Abstract excerpt
OBJECTIVES: To develop an immune-competent animal model for mucosally derived squamous cell carcinoma (SCCA). STUDY DESIGN: Fifteen Fischer 344 rats were inoculated with 1, 2, 5, 10, or 20 x 10(6) FAT7 cells in their flanks. The animals were observed for tumor growth and metastasis. RESULTS: All animals developed tumors that grew exponentially. Pulmonary metastases developed in all animals and 13% developed lymph...
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