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Article

Staphylococcus aureus IsdG and IsdI, heme-degrading enzymes with structural similarity to monooxygenases.

The Journal of biological chemistry - 28 Jan 2005

Wu Ruiying, Skaar Eric Patrick, Zhang Rongguang, Joachimiak Grazyna, Gornicki Piotr, Schneewind Olaf, Joachimiak Andrzej

Abstract excerpt

Heme-degrading enzymes are involved in human diseases ranging from stroke, cancer, and multiple sclerosis to infectious diseases such as malaria, diphtheria, and meningitis. All mammalian and microbial enzymes identified to date are members of the heme oxygenase superfamily and assume similar monomeric structures with an all alpha-helical fold. Here we describe the crystal structures of IsdG and IsdI, two...

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Identifiers

PMID: 15520015
DOI: 10.1074/jbc.M409526200
PMCID: PMC2792019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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