Article
Association of the macrophage activating factor (MAF) precursor activity with polymorphism in vitamin D-binding protein.
Anticancer research - 1 Jan 2000
Nagasawa Hideko, Sasaki Hideyuki, Uto Yoshihiro, Kubo Shinichi, Hori Hitoshi
Abstract excerpt
BACKGROUND: Serum vitamin D-binding protein (Gc protein or DBP) is a highly expressed polymorphic protein, which is a precursor of the inflammation-primed macrophage activating factor, GcMAF, by a cascade of carbohydrate processing reactions. In order to elucidate the relationship between Gc polymorphism and GcMAF precursor activity, we estimated the phagocytic ability of three homotypes of Gc protein, Gc1F-1F,...
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