Article
[Glucose 6-phosphate dehydrogenase deficiency: a protection against malaria and a risk for hemolytic accidents].
Comptes rendus biologies - 1 Aug 2004
Wajcman Henri, Galactéros Frédéric
Abstract excerpt
Glucose 6-phosphate dehydrogenase (G6PD) catalyses the first step of the pentose phosphate pathway, which in the RBC leads to the formation of NADPH, essential to prevent the cell from an oxidative stress. Worldwide, more than 400 million people (90% being males) are affected by G6PD deficiency, in regions that are, or have been, endemic for malaria and in populations originating from these regions. RBCs with low...
Topics
- Animals
- Erythrocytes
- Evolution, Molecular
- Female
- Genetic Diseases, X-Linked
- Genetic Predisposition to Disease
- Glucosephosphate Dehydrogenase
- Glucosephosphate Dehydrogenase Deficiency
- Hemolysis
- Humans
- Immunity, Innate
- Malaria
- Male
- Models, Molecular
- Mutation
- NADP
- Oxidants
- Oxidation-Reduction
