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Increased cell‐free fetal DNA release after apoptosis and sterile inflammation in human trophoblast cells

7 Jul 2021

Abstract excerpt

PROBLEM: Cell-free fetal DNA (cffDNA) shed from the placenta can be detected in maternal blood and increases incrementally during gestation. Concentrations are further elevated with pregnancy complications. Specific activators of cffDNA release in such complications have not been identified. Here, we use trophoblast cells from early and term placenta to examine cffDNA release following apoptosis, infection, and...

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PMID: 34233077
DOI: 10.1111/aji.13483

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