Article
Gene expression of parathyroid tumors: molecular subclassification and identification of the potential malignant phenotype.
Cancer research - 15 Oct 2004
Haven Carola J, Howell Viive M, Eilers Paul H C, Dunne Robert, Takahashi Masayuki, van Puijenbroek Marjo, Furge Kyle, Kievit Job, Tan Min-Han, Fleuren Gert Jan, Robinson Bruce G, Delbridge Leigh W, Philips Jeanette, Nelson Anne E, Krause Ulf, Dralle Henning, Hoang-Vu Cuong, Gimm Oliver, Morreau Hans, Marsh Deborah J, Teh Bin T
Abstract excerpt
Parathyroid tumors are heterogeneous, and diagnosis is often difficult using histologic and clinical features. We have undertaken expression profiling of 53 hereditary and sporadic parathyroid tumors to better define the molecular genetics of parathyroid tumors. A class discovery approach identified three distinct groups: (1) predominantly hyperplasia cluster, (2) HRPT2/carcinoma cluster consisting of sporadic...
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