Article
Novel missense polymorphism in the regulator of G-protein signaling 10 gene: analysis of association with schizophrenia.
Psychiatry and clinical neurosciences - 1 Oct 2004
Hishimoto Akitoyo, Shirakawa Osamu, Nishiguchi Naoki, Aoyama Shinsuke, Ono Hisae, Hashimoto Takeshi, Maeda Kiyoshi
Abstract excerpt
Dysfunction of neuronal signal transduction via G-protein has previously been speculated to be involved in the pathophysiology of schizophrenia. Regulator of G-protein signaling (RGS) is a protein that acts as a GTPase-activator for Galpha protein. A total of 33 Japanese patients with schizophrenia were screened for mutations in the coding region of the RGS10 gene, and a novel missense polymorphism (Val38Met) in...
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