Article
Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance?
The Journal of investigative dermatology - 1 Nov 2004
Rosenblum Michael D, Olasz Edit B, Yancey Kim B, Woodliff Jeffrey E, Lazarova Zelmira, Gerber Kimberly A, Truitt Robert L
Abstract excerpt
CD200 (OX-2) is a transmembrane glycoprotein that transmits an immunoregulatory signal through the CD200 receptor (CD200R) to attenuate inflammatory reactions and promote immune tolerance. CD200 expression in the skin has not been described previously. We now report that freshly isolated cells of the murine epidermis contain a subpopulation of major histocompatibility complex (MHC) class II-negative, CD3-negative...
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