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Article

Thioredoxin modulates activator protein 1 (AP-1) activity and p27Kip1 degradation through direct interaction with Jab1.

Oncogene - 25 Nov 2004

Hwang Chae Young, Ryu Yeung Sook, Chung Mi-Sun, Kim Kwang Dong, Park Sung Sup, Chae Suhn-Kee, Chae Ho Zoon, Kwon Ki-Sun

Abstract excerpt

Thioredoxin (Trx) is a cellular redox enzyme that plays multiple roles in regulating cell growth and apoptosis. Jun activation domain-binding protein 1 (Jab1) was originally identified as a coactivator of activator protein 1 (AP-1) transcription and was also shown to promote degradation of the cy...

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PMID: 15480426
DOI: 10.1038/sj.onc.1208116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15480426-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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