Article
Ex vivo differentiation of human adult bone marrow stem cells into cardiomyocyte-like cells.
Biochemical and biophysical research communications - 12 Nov 2004
Shim Winston S N, Jiang Shujia, Wong Philip, Tan Jack, Chua Yeow Leng, Tan Yong Seng, Sin Yoong Kong, Lim Chong Hee, Chua Terrance, Teh Ming, Liu Te Chih, Sim Eugene
Abstract excerpt
Bone marrow mesenchymal stem cells have been shown to transdifferentiate into cardiomyocytes after 5-azacytidine treatment or co-culturing with rodent cardiomyocytes. We investigate if adult human bone marrow stem cells can be differentiated ex vivo into cardiomyocyte-like cells (CLCs) independent of cytotoxic agents or co-culturing technique. Sternal bone marrow was collected from 16 patients undergoing coronary...
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