Article
Parallel reductions in stomatin and Na,K-ATPase through the exosomal pathway during reticulocyte maturation in dogs: stomatin as a genotypic and phenotypic marker of high K(+) and low K(+) red cells.
The Journal of veterinary medical science - 1 Jul 2010
Komatsu Tomohiko, Sato Kota, Otsuka Yayoi, Arashiki Nobuto, Tanaka Kohei, Tamahara Satoshi, Ono Ken-ichiro, Inaba Mutsumi
Abstract excerpt
Dogs can be divided into two genetic groups (a minor HK phenotype and a major LK phenotype) based on erythrocyte monovalent cation concentrations, which are controlled by the putative hk and lk allelic genes. HK dogs retain Na,K-ATPase in their erythrocytes due to the high activity of the enzyme in their precursor cells, whereas total loss of reticulocyte Na,K-ATPase occurs in LK dogs. Here, we report that the...
Topics
- Amino Acid Sequence
- Anemia
- Animals
- Antibodies, Monoclonal
- Cations
- Dogs
- Erythrocyte Membrane
- Erythrocytes
- Genotype
- Humans
- Membrane Proteins
- Mice
- Molecular Sequence Data