Article
Perturbed sex steroid status in men with idiopathic osteoporosis and their sons.
The Journal of clinical endocrinology and metabolism - 1 Oct 2004
Van Pottelbergh I, Goemaere S, Zmierczak H, Kaufman J M
Abstract excerpt
We reported previously that a gender-specific defect of acquisition of lumbar bone mass plays an important role in the pathogenesis of male idiopathic osteoporosis (IO) and that there is a strong heritability of this maturational defect, which is particularly manifest in sons of men with IO. A hypothetical role of an altered sex steroid status and/or of a (TTTA)(n)- repeat polymorphism of the aromatase (CYP19)...
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