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Article

The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone (GnRH)-producing neurons.

Human molecular genetics - 15 Nov 2004

Cariboni Anna, Pimpinelli Federica, Colamarino Sophia, Zaninetti Roberta, Piccolella Margherita, Rumio Cristiano, Piva Flavio, Rugarli Elena I, Maggi Roberto

Abstract excerpt

X-linked Kallmann's syndrome (KS) is a genetic disease characterized by anosmia and hypogonadism due to impairment in the development of olfactory axons and in the migration of gonadotropin-releasing hormone (GnRH)-producing neurons. Deletions or point mutations of a gene located at Xp22.3 (KAL1) are responsible for the disease. This gene encodes for a secreted heparin-binding protein (KAL or anosmin-1) which...

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PMID: 15471890
DOI: 10.1093/hmg/ddh309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The product of X-linked Kallmann's syndrome gene (KAL1) affects the migratory activity of gonadotropin-releasing hormone (GnRH)-producing neurons.PMID 15471890Read ↗

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