Article
Diversity in fibroblast growth factor receptor 1 regulation: learning from the investigation of Kallmann syndrome.
Journal of neuroendocrinology - 1 Feb 2008
Kim S-H, Hu Y, Cadman S, Bouloux P
Abstract excerpt
The unravelling of the genetic basis of the hypogonadotrophic hypogonadal disorders, including Kallmann syndrome (KS), has led to renewed interest into the developmental biology of gonadotrophin-releasing hormone (GnRH) neurones and, more generally, into the molecular mechanisms of reproduction. KS is characterised by the association of GnRH deficiency with diminished olfaction. Until recently, only two...
Topics
- Cell Movement
- Extracellular Matrix Proteins
- Gastrointestinal Hormones
- Genotype
- Gonadotropin-Releasing Hormone
- Heparitin Sulfate
- History, 19th Century
- History, 20th Century
- Humans
- Kallmann Syndrome
- Nerve Tissue Proteins
- Neurons
- Neuropeptides
- Phenotype
- Receptor, Fibroblast Growth Factor, Type 1
- Receptors, G-Protein-Coupled
- Receptors, Peptide
- Signal Transduction