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Article

Defective migration of neuroendocrine GnRH cells in human arrhinencephalic conditions

17 Sept 2010

Abstract excerpt

Patients with Kallmann syndrome (KS) have hypogonadotropic hypogonadism caused by a deficiency of gonadotropin-releasing hormone (GnRH) and a defective sense of smell related to olfactory bulb aplasia. Based on the findings in a fetus affected by the X chromosome–linked form of the disease, it has been suggested that hypogonadism in KS results from the failed embryonic migration of neuroendocrine GnRH1 cells from...

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PMID: 20940512
DOI: 10.1172/jci43699

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