Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular defects in coagulation Factor VIII and their impact on Factor VIII function.

Vox sanguinis - 1 Aug 2002

Saenko E L, Ananyeva N, Kouiavskaia D, Schwinn H, Josic D, Shima M, Hauser C A E, Pipe S

Abstract excerpt

Molecular defects in Factor VIII (FVIII), such as haemophilia A-related mutations or denaturative conformational changes, may affect the stability of FVIII as well as its interactions with physiological activators, von Willebrand Factor, phospholipid, or conformationally sensitive antibodies. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation
Share to Factor VIII
Share to Hemophilia A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Protein Conformation

Source

Identifiers

PMID: 12201837
DOI: 10.1046/j.1423-0410.2002.00183.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12201837-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular defects in coagulation Factor VIII and their impact on Factor VIII function.PMID 12201837Read ↗

Molecular etiology of factor VIII deficiency in hemophilia A.Semantic proximity Read ↗

The p. Arg1800His Mutation of Factor VIII Results in Moderate Hemophilia A Due to Defective Processing and Stability of Functional Protein.Semantic proximity Read ↗

Molecular mechanisms of mild and moderate hemophilia A.Semantic proximity Read ↗

Genetic analysis of non-severe hemophilia A phenotype with A discrepancy between one-stage and chromogenic factor VIII activity assays.Semantic proximity Read ↗

Blood coagulation factor VIII: An overview.Semantic proximity Read ↗

Factor XIII deficiency diagnosis: Challenges and tools.Semantic proximity Read ↗

The protein structure and effect of factor VIII.Semantic proximity Read ↗

Molecular and clinical aspects of factor VII deficiency.Semantic proximity Read ↗

Haemophilia A and von Willebrand's disease.Semantic proximity Read ↗

Functional roles of the factor VIII B domainSemantic proximity Read ↗

Factor V haemostatic diathesis impairing thrombin activation, membrane binding and circulating antigen level due to a novel compound heterozygous mutation, Leu1821Ser and Gly2192Cys.Semantic proximity Read ↗

Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.