Article
Use of molecular simulation for mapping conformational CYP2E1 epitopes.
The Journal of biological chemistry - 3 Dec 2004
Vidali Matteo, Hidestrand Mats, Eliasson Erik, Mottaran Elisa, Reale Emanuela, Rolla Roberta, Occhino Giuseppa, Albano Emanuele, Ingelman-Sundberg Magnus
Abstract excerpt
The identification of the epitopes recognized by autoantibodies against cytochrome P450s (CYPs) associated with drug-induced hepatotoxicity is difficult because of their conformational nature. In the present investigation, we used a novel approach based on the analysis of the whole molecule antigenic capacity following single amino acid substitutions to identify the conformational epitopes on CYP2E1. A molecular...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.