Article
Interaction between an 11betaHSD1 gene variant and birth era modifies the risk of hypertension in Pima Indians.
Hypertension (Dallas, Tex. : 1979) - 1 Nov 2004
Franks Paul W, Knowler William C, Nair Saras, Koska Juraj, Lee Yong-Ho, Lindsay Robert S, Walker Brian R, Looker Helen C, Permana Paska A, Tataranni P Antonio, Hanson Robert L
Abstract excerpt
11beta-hydroxysteroid dehydrogenase type 1 (11betaHSD1) is a candidate gene for hypertension, diabetes, and obesity through altered glucocorticoid production. This study explored the association of 11betaHSD1 gene variants with diabetes, hypertension, and obesity in a longitudinal population study of American Indians (N=918; exams=5508). In multivariate mixed models assuming an additive effect of genotype, a 5'...
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