Article
BCR-ABL fusion transcript types and levels and their interaction with secondary genetic changes in determining the phenotype of Philadelphia chromosome-positive leukemias.
Blood - 15 Dec 2008
Jones Dan, Luthra Rajyalakshmi, Cortes Jorge, Thomas Deborah, O'Brien Susan, Bueso-Ramos Carlos, Hai Seema, Ravandi Farhad, de Lima Marcos, Kantarjian Hagop, Jorgensen Jeffrey L
Abstract excerpt
It remains unresolved how different BCR-ABL transcripts differentially drive lymphoid and myeloid proliferation in Philadelphia chromosome-positive (Ph(+)) leukemias. We compared BCR-ABL transcript type and level with kinase domain (KD) mutation status, genotype, and phenotype in 1855 Ph(+) leukemias. Compared with e1a2/p190 BCR-ABL cases, de novo e13-e14a2/p210 Ph(+) lymphoid leukemia more frequently showed...
Topics
- Cell Transformation, Neoplastic
- Chromosome Aberrations
- Core Binding Factor Alpha 2 Subunit
- DNA-Binding Proteins
- Fusion Proteins, bcr-abl
- Gene Amplification
- Genotype
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive