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Genetic Basis of Cancer of the Kidney

15 Sept 2004

Abstract excerpt

Studies during the past two decades have shown that kidney cancer is not a single disease; it is made up of a number of different types of cancer that occur in this organ. Clear cell renal carcinoma is characterized by mutation of the VHL gene. The VHL gene product forms a heterotrimeric complex with elongin C, elongin B, and Cul-2 to target hypoxia-inducible factors 1 and 2alpha for ubiquitin-mediated...

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Share to Epigenetics and DNA Methylation
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PMID: 15448018
DOI: 10.1158/1078-0432.ccr-050013

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